The reaction that occurs when chemicals enter the bloodstream through the skin, eyes, mouth, or lungs is called a systemic reaction. This happens because the chemicals get absorbed into the body, travel through the bloodstream, and can cause damage to the entire body, potentially affecting organs and tissues throughout. Such exposure can lead to both local damage (at the point of contact) and systemic damage (to internal organs), sometimes without immediate visible warning signs. This systemic damage means the entire body can be harmed due to the chemicals traveling via the bloodstream after entering through those routes.