Mice are generally scared of humans because humans are large and threatening to these small, vulnerable creatures. Mice tend to fear people as natural predators and often avoid human presence, seeking shelter in places where humans are less likely to frequent, such as wall cavities, attics, and basements. However, mice that live alongside humans long enough may become more accustomed and less fearful of some individuals, especially if motivated by food availability. Despite this, the innate fear of humans helps explain why mice bites are rare and why mice try to stay hidden from people. This fear is a natural survival mechanism for mice as they are low in the food chain and vulnerable to many predators including humans.