The best over-the-counter (OTC) sleep aids for 2025 include a mix of supplements with different active ingredients, often chosen based on individual needs like improving sleep quality, reducing sleep latency, or supporting relaxation. Top recommended OTC sleep aids of 2025 are:

• Nutricost Sleep Aid Complex (best overall) with a robust formulation of sleep-enhancing nutrients and herbs.
• Unisom (contains doxylamine, a sedating antihistamine), Tylenol PM, and Vicks ZzzQuil were ranked as the top pharmaceutical OTC options by pharmacists.
• Natural options such as Nature Made and Nature’s Bounty are leading natural sleep aid brands.
• Other notable natural ingredients include melatonin, L-theanine, glycine, valerian root, magnesium, and herbal blends (like chamomile, lemon balm) for relaxation and improved sleep quality.
• For value and ease of use, Nutravita Natural Night Complex and Paused Sleep Aid capsules are also highly rated for affordability and effective ingredient blends.

OTC antihistamine-based sleep aids like diphenhydramine and doxylamine are widely used but may cause next-day grogginess and tolerance with prolonged use. Natural supplements like melatonin and L-theanine have fewer side effects and may be better for sleep maintenance or minimal next-day effects. Ultimately, the best OTC sleep aid depends on specific sleep issues, preference for natural vs pharmaceutical, potential side effects, and convenience of use. Consultation with a healthcare provider is advised for persistent or serious sleep problems.