The calorie content of a McDonald's Big Mac varies slightly by source and location but generally falls between 524 and 580 calories per sandwich.

• One source states a Big Mac has 550 calories, with 30 grams of fat, 45 grams of carbs, and 25 grams of protein.

• Another source mentions 540 calories with a macronutrient breakdown of 34% carbs, 47% fat, and 19% protein.

• According to the official McDonald's US nutrition data referenced on Wikipedia, the Big Mac contains about 580 calories, 34 grams of fat, and 25 grams of protein.

• One Dutch source cites 524 calories per 229.25g portion.

In summary, the Big Mac's calorie count typically ranges from about 524 to 580 calories depending on location and exact serving size.