Yes, it is safe to take Advil (ibuprofen) and Tylenol (acetaminophen) together for extra pain relief, as they work through different mechanisms with minimal overlapping side effects. However, it is important to follow recommended dosages and avoid this combination if you have stomach ulcers, kidney disease, liver problems, or allergies to NSAIDs. For optimal and around-the-clock pain relief, it is often recommended to alternate the two medications every 3 to 4 hours rather than taking them exactly at the same time. For example, taking ibuprofen first and then acetaminophen 3 to 4 hours later is a common schedule. Be cautious of "hidden" acetaminophen in other medications to avoid overdose and consult a healthcare provider if taking these medicines for more than a few days or if you have chronic health issues.