It is generally not recommended to take Advil (ibuprofen) on an empty stomach because it can increase the risk of gastrointestinal irritation such as nausea, stomach pain, heartburn, and indigestion. Advil is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the stomach lining by blocking enzymes that protect it. Taking it with food or a small snack helps create a buffer and reduce stomach discomfort. However, taking low doses of ibuprofen (up to 1200 mg daily in divided doses) on an empty stomach for short-term use is considered relatively safe by some sources and provides faster pain relief. The risk of stomach irritation from ibuprofen depends more on individual factors like history of stomach ulcers, age, other medications, and duration of use rather than just food intake. Best practices to minimize stomach upset when taking Advil include taking it with a full glass of water, avoiding alcohol and smoking, staying upright for 10 minutes after taking it, and considering taking it with milk or light food if a meal is not immediately available. In summary:

• Taking Advil on an empty stomach can irritate the stomach lining and increase risk of side effects.
• Taking it with food or a small snack is safer and recommended.
• Low-dose, short-term use on an empty stomach may be acceptable for some people.
• Individuals with risk factors (ulcers, GERD, elderly, certain medications) should avoid taking it without food.

This guidance applies to typical over-the-counter dosages and short-term use. For higher doses or long-term use, always consult a healthcare provider. References:

• Advil can irritate stomach lining; food reduces risk of GI side effects.

• Some sources say low-dose ibuprofen up to 1200mg daily can be taken on empty stomach safely.

• Gastroenterologist warns against taking painkillers like Advil on empty stomach due to ulcer risk.

• Individual risk factors matter greatly for GI side effects with ibuprofen.