Yes, it is generally safe to take aspirin with paracetamol together. They work in different ways for pain and fever relief, and combining them can sometimes provide enhanced effect. However, it is important to not exceed the recommended doses for either medication and to use this combination cautiously, preferably under medical supervision, especially if used for a longer period. Both drugs can put strain on the liver and kidneys, so monitoring is advised if taken regularly. Also, aspirin should not be combined with other NSAIDs like ibuprofen without doctor advice. Children under 16 should avoid aspirin due to the risk of Reye's syndrome, while paracetamol is considered safer for general use.