It is generally safe to take ibuprofen with amoxicillin. Ibuprofen is commonly used to relieve pain and fever while amoxicillin is an antibiotic used to treat infections, and these two do not have significant harmful interactions. However, combining them may increase the risk of gastrointestinal side effects such as stomach pain, nausea, or in rare cases, gastrointestinal bleeding. People with kidney, heart, or liver problems should be cautious and consult a healthcare provider before using this combination. Monitoring for any adverse symptoms and limiting ibuprofen use to the shortest duration necessary is advisable. Always consult a healthcare professional for personalized advice before combining these medications.