Yes, you can generally take Pepcid (famotidine) and Tums (calcium carbonate) together for relief from heartburn and acid reflux. However, it is best to space out their administration by at least 1 to 2 hours. This spacing helps avoid reducing the absorption of Pepcid by about 20-30%, allowing each medication to work effectively. Pepcid works by decreasing stomach acid production, while Tums neutralizes existing stomach acid, so they can complement each other when used properly. Do not exceed the recommended dosage of either medication and consult a healthcare provider if you need to use both regularly or have ongoing digestive symptoms.