Yes, it is generally safe to take Tylenol (acetaminophen) and Benadryl (diphenhydramine) together. There are no known adverse interactions between these two medications, and several over-the-counter products actually combine both ingredients in one pill for maximum effect. Tylenol helps relieve pain and reduce fever, while Benadryl is primarily used to relieve allergic symptoms and can also cause sedation. However, it is important to follow dosage instructions carefully and not exceed the recommended dose for either medication to avoid potential side effects like liver damage from acetaminophen overdose or serious effects from too much diphenhydramine. These medications are typically recommended for short-term use, and if symptoms persist, consulting a healthcare professional is advised.