Yes, Tylenol (acetaminophen) can be taken on an empty stomach. It is generally safe to do so and does not require food intake to avoid stomach irritation. Tylenol is gentler on the stomach than NSAIDs like ibuprofen or naproxen, which are more likely to cause stomach upset and therefore usually need to be taken with food. Taking Tylenol with a full glass of water is recommended, and taking it on an empty stomach may even allow it to be absorbed faster and start working sooner. However, some people may experience mild stomach upset or nausea when taking Tylenol without food, in which case taking it with food could help ease those effects.