Yes, Tylenol (acetaminophen) can be taken with amoxicillin. There are no major drug interactions between these two medications, and they can be used together safely to manage infections and associated pain or fever. However, it is important to follow dosing instructions for both medications. People with liver conditions should use caution with Tylenol, and consulting a healthcare provider is advised if there are specific health concerns. A gap of about 30 minutes between doses is sometimes recommended, but they can generally be taken together without issues.