It is generally safe to take Tylenol (acetaminophen) with Mucinex (guaifenesin), as they address different symptoms and have no major drug interactions. However, caution is needed to avoid taking too much acetaminophen, which can harm the liver. Always follow dosage instructions on the labels and be mindful not to exceed the maximum daily dose of acetaminophen (usually 4,000 mg for adults). It's also wise to consult a doctor if there are existing health conditions, use other medications, or if you're pregnant or breastfeeding. Avoid combining with alcohol to prevent liver damage. Taking Tylenol and Mucinex at different times, spaced by 4-6 hours, may help reduce risk and optimize effectiveness.