It is generally safe to take Tylenol (acetaminophen) with prednisone. These two medications do not have known direct interactions and can usually be used together without issue. Tylenol helps relieve pain and reduce fever, while prednisone is a corticosteroid used to reduce inflammation and suppress the immune system. However, it is important to follow the recommended dosages and consult a healthcare provider before combining them, especially if there are liver issues or other medications involved. Prednisone should be taken with food to avoid stomach irritation, while Tylenol does not have this requirement. Also, avoiding other acetaminophen-containing products while taking Tylenol is advised to prevent overdosing. In summary, taking Tylenol with prednisone is typically safe, but taking into consideration individual health conditions and other medications is essential, and medical advice is recommended.