Short answer: It’s generally advised to avoid alcohol while taking Accutane (isotretinoin). If you do drink, do so only in moderation and after discussing with your dermatologist. What to know

• Liver strain: Both isotretinoin and alcohol are processed by the liver. Combining them can raise liver enzyme levels and increase the risk of liver injury.

• Blood tests: Isotretinoin treatment usually involves regular liver function tests and lipid checks. Drinking can confound these results and complicate monitoring.

• Side effects and dehydration: Alcohol can worsen common Accutane side effects such as dehydration and dry skin, and may exacerbate mood changes in some individuals.

• Variation by case: Some sources suggest avoiding alcohol entirely during treatment, while others say if you choose to drink, keep it minimal and ensure you stay hydrated and monitor for any symptoms. This is highly individual, so consult your prescribing dermatologist for personalized guidance.

Practical guidance

• If you’re pursuing treatment, plan to minimize or avoid alcohol during the course of therapy.
• If you accidentally have a drink, monitor for signs of liver issues (jaundice, dark urine, persistent nausea, fatigue) and contact your clinician if any concern arises.
• Maintain hydration, follow all dosing and lab-testing schedules, and discuss any alcohol intake with your dermatologist to avoid delaying treatment.

Note: The sources reflect general medical guidance and patient-facing explanations; individual recommendations may vary based on your medical history and treatment plan. If you want, I can summarize any one source in more detail or help you talk to your dermatologist about this topic.