It’s generally possible to drink alcohol while taking penicillin, but there are important caveats to consider. Key points

• Penicillin antibiotics (including phenoxymethylpenicillin) are not known to have dangerous interactions with moderate alcohol in most people. You can often drink in moderation without a dangerous chemical reaction, but it may affect how you feel and recover.

• Even if the interaction is not life-threatening, alcohol can worsen common antibiotic side effects (nausea, stomach upset, diarrhea) and can slow your recovery by reducing energy or hydration.

• Some people may metabolize alcohol differently when ill or taking medications, so it’s wise to listen to your body and avoid heavy drinking if you’re feeling unwell or dizzy.

• Always follow your clinician’s specific advice, especially if you have other health conditions, are taking additional medications, or were prescribed a particular antibiotic regimen. If in doubt, contact the prescribing clinician for personalized guidance.

Practical guidance

• If you choose to drink, do so in moderation and ensure you stay hydrated and well-nourished. Avoid binge drinking, as it is more likely to cause side effects or dehydration.

• Monitor how you feel after drinking while on penicillin. If you experience increased nausea, vomiting, diarrhea, or dizziness, reduce or stop alcohol and seek medical advice.

• Do not mix alcohol with antibiotics that have known strong interactions; your pharmacist or doctor can confirm whether your specific penicillin product has any cautions.

Bottom line

• For many people, moderate alcohol is not contraindicated with penicillin, but it can hinder recovery and amplify side effects. If you’re unsure or have other health risks, check with your healthcare provider for advice tailored to your situation.