It is generally not recommended to drink alcohol while taking prednisone because the combination can increase the risk of several side effects and complications. Although there is no direct drug interaction, both prednisone and alcohol can suppress the immune system and stress the liver, potentially causing these combined side effects to worsen. Risks include stomach irritation or ulcers, changes in blood sugar, dehydration, mood changes, high blood pressure, and liver damage. The severity of these risks depends on the dose and duration of prednisone treatment as well as individual health conditions. Some sources say moderate alcohol consumption might be safe for people on low-dose or short-term prednisone, but the safest approach is to avoid alcohol entirely during treatment. It is best to consult a healthcare provider for personalized advice based on the specific prednisone regimen and health status. After finishing prednisone, waiting at least a week before drinking alcohol is advisable to avoid complications. In summary, abstaining from alcohol while taking prednisone is the safest choice due to the amplified risk of side effects and health problems when the two are combined.