Drinking alcohol while taking amitriptyline is generally not recommended because the combination can increase sedation, drowsiness, dizziness, impaired motor coordination, and slowed reaction times. Even small amounts of alcohol may amplify these side effects and increase risks such as respiratory depression in rare cases. Alcohol may also reduce the effectiveness of amitriptyline in treating mental health conditions or worsen symptoms of depression since alcohol itself is a depressant. For people with liver or kidney issues, the risks are even higher because both alcohol and amitriptyline are metabolized by the liver. If alcohol is consumed, it should be in very limited amounts, ideally once a steady dose of amitriptyline has been established, and waiting at least 24 to 48 hours after the last dose can reduce risks. However, many clinicians advise complete abstinence from alcohol during amitriptyline therapy, especially at higher doses or during the initial titration phase. In summary, it is safest to avoid alcohol when taking amitriptyline due to potential serious side effects and reduced medication effectiveness.