It is not recommended to drink alcohol while taking Accutane (isotretinoin). Both Accutane and alcohol are processed by the liver and can strain it, increasing the risk of liver damage and elevated liver enzymes. Drinking alcohol can also raise triglyceride levels, which Accutane can already increase, potentially leading to dangerous conditions like pancreatitis. Additionally, alcohol may worsen side effects such as dehydration, dry skin, and mood disturbances, and can interfere with the effectiveness and safety monitoring of the medication. Most doctors advise complete abstinence from alcohol during the entire course of Accutane treatment and potentially for some time after finishing it to avoid these risks.