It is generally not recommended to drink alcohol while taking Sudafed (pseudoephedrine). While not necessarily dangerous in all cases, mixing Sudafed and alcohol can lead to unwanted side effects such as increased heart rate, dizziness, blurred vision, anxiety, and drowsiness. Sudafed is a stimulant and can mask the sedative effects of alcohol, potentially causing a person to drink more than intended and increasing the risk of alcohol poisoning or injuries. Additionally, alcohol can reduce the effectiveness of Sudafed by contributing to nasal congestion and weakening the immune system, which may prolong symptoms. If alcohol is consumed, it is safest to wait until Sudafed has cleared from the body, which can take from about 12 to 30 hours depending on the Sudafed variant. For those with high blood pressure, heart conditions, or other vulnerabilities, avoiding alcohol while on Sudafed is particularly important. Consulting a healthcare provider for personalized advice is recommended. In summary, drinking alcohol while taking Sudafed is discouraged due to potential side effects and reduced effectiveness of the medication. Waiting at least 24 hours after taking Sudafed before drinking alcohol is advised for safety.