It is generally considered safe to take acetaminophen (Tylenol) during pregnancy when used as directed for short-term pain or fever relief. Major medical groups like the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine recommend acetaminophen as one of the safest options for pregnant individuals compared to alternatives like ibuprofen or aspirin, which pose more risks to the fetus.

However, recent studies and regulatory agencies including the FDA have raised concerns about potential associations between long-term or chronic use of acetaminophen during pregnancy and neurological conditions such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in children. These potential risks are not definitively proven causal links but are under ongoing scientific investigation. The FDA advises minimizing use, especially for low-grade fevers when medication may not be necessary, and encourages using the lowest effective dose for the shortest duration.

In summary, acetaminophen remains the preferred pain and fever medication during pregnancy if needed, but pregnant persons are advised to consult their healthcare provider to weigh benefits and risks and avoid unnecessary or prolonged use.

If symptoms last or worsen, or if there is concern about medication use in pregnancy, a healthcare provider should be consulted.