Omeprazole can generally be taken during pregnancy, and studies have not found an increased risk of major birth defects, spontaneous abortions, or perinatal complications associated with its use. However, it is usually recommended to avoid omeprazole especially during the first trimester when the baby's major organs are developing. Healthcare providers often suggest trying lifestyle and dietary changes first, and only using omeprazole if necessary, preferably after consulting a doctor. Omeprazole crosses the placenta, so the decision to use it during pregnancy should involve weighing the benefits against potential, though not proven, risks to the fetus. It is also considered generally safe during breastfeeding, but advice from a healthcare provider is important in all cases.