It is generally not recommended to take Tylenol (acetaminophen) and drink alcohol together due to the increased risk of serious liver damage. Both substances are processed by the liver, and when combined, they can interfere with each other's metabolism. This can lead to the buildup of toxic compounds in the liver, increasing the risk of liver inflammation, damage, or failure, even when Tylenol is taken at regular doses. Drinking alcohol moderately while taking Tylenol occasionally might be less risky for healthy individuals, but heavy or frequent drinking combined with acetaminophen use can be particularly harmful. People with existing liver issues or who consume alcohol regularly should avoid this combination entirely to prevent liver toxicity. If there is any concern about using both, consulting a healthcare provider is advised. In summary, to protect the liver, it is safest to avoid consuming alcohol while taking Tylenol. If necessary, separate the intake of Tylenol and alcohol by at least 24 hours to minimize risks.