The main cast of the TV series Car 54, Where Are You? (1961–1963) includes:

• Joe E. Ross as Officer Gunther Toody
• Fred Gwynne as Officer Francis Muldoon
• Beatrice Pons as Lucille Toody
• Al Lewis as Officer Leo Schnauser
• Charlotte Rae as Sylvia Schnauser
• Paul Reed as Captain Martin Block
• Hank Garrett as Officer Ed Nicholson
• Bruce Kirby as Officer Kissel
• Jimmy Little as Sergeant Jim McBride
• Nipsey Russell as Officer Anderson
• Albert Henderson as Officer Dennis O'Hara
• Ruth Masters as Mrs. Muldoon (Francis's mother)
• Jim Gormley as Officer Nelson
• Joe Warren as Officer Steinmetz
• Frederick O'Neal as Officer Wallace
• Others in supporting roles

For the 1994 film adaptation Car 54, Where Are You? , the cast includes:

• David Johansen as Officer Gunther Toody
• John C. McGinley as Officer Francis Muldoon
• Fran Drescher as Velma Velour
• Nipsey Russell as Police Captain Dave

This sitcom focuses on the comedic adventures of two mismatched New York City police officers patrolling the fictional 53rd precinct in The Bronx.