The main cast of "How I Met Your Father" includes:

• Hilary Duff as Sophie Tompkins, the lead character and a hopelessly romantic photographer searching for her soulmate.
• Christopher Lowell as Jesse Walker, an aspiring musician and Uber driver who lives with Sid.
• Francia Raisa as Valentina Morales, Sophie's best friend and roommate, an impulsive assistant-stylist.
• Suraj Sharma as Sid, Jesse's best friend and bar owner, engaged to Hannah.
• Tom Ainsley as Charlie Winthrop, a British aristocrat who follows Valentina to New York and works as a bartender.
• Tien Tran as Ellen Gilbert, Jesse's adoptive sister who moves to New York after her divorce.
• Kim Cattrall as future Sophie, who narrates the story from the year 2050

Supporting and guest roles include actors such as Josh Peck as Drew, Leighton Meester as Meredith, Paget Brewster as Lori (Sophie's mother), and appearances by original "How I Met Your Mother" cast members like Neil Patrick Harris as Barney Stinson and Cobie Smulders as Robin Scherbatsky

. This ensemble forms the core group around which the series revolves, blending new characters with nostalgic cameos from the original show.