Codoliprane is a medication that contains two active ingredients: paracetamol (also known as acetaminophen) and codeine. It is used as an analgesic (pain reliever) to treat moderate pain that is not adequately relieved by other analgesics like paracetamol or ibuprofen alone. The codeine component is an opioid analgesic that works by acting on the brain's pain perception, while paracetamol helps reduce pain and fever. Codoliprane is indicated for short- term use in patients over 12 years old. It is available in different dosages, notably 500 mg paracetamol combined with 30 mg codeine, and 400 mg paracetamol combined with 20 mg codeine, in forms such as tablets or capsules. The medication should be used with caution or avoided in certain conditions, including:

• Patients with respiratory issues, severe liver, kidney, or heart problems.
• Those with a history of convulsive disorders.
• Patients with increased intracranial pressure, Addison's disease, hypothyroidism, or certain gastrointestinal conditions.
• Avoid in productive cough since codeine can inhibit expectoration.
• Caution is also recommended when combined with central nervous system depressants like benzodiazepines or alcohol.

Typical adult dosing for Codoliprane 400 mg/20 mg is 1 to 2 tablets every 6 hours as needed, without exceeding 6 to 8 tablets per day depending on the severity of pain, and similar precautions apply for the 500 mg/30 mg dosage. For adolescents, dosing is weight-based and should be strictly followed under medical supervision. The use of Codoliprane is generally for managing moderate acute pain over a short period. If pain persists or worsens, a doctor should be consulted. In summary, Codoliprane is a dual-action analgesic combining paracetamol and codeine, used for moderate pain relief in older children and adults with specific dosing and safety warnings to observe due to the opioid component.