There is limited research on the effects of smoking weed on metabolism. However, some studies suggest that chronic cannabis use and CB1R activation may negatively affect metabolic actions of insulin. Other studies on mice and rats have found a correlation between cannabis use and reduction in BMI. However, its important to note that cannabis isnt a prescription for weight loss, and it wont help you lose weight if you dont exercise and have unhealthy eating habits. Additionally, smoking cannabis can cause rapid changes in heart rate and diastolic blood pressure, conjunctival suffusion, dry mouth and throat, increased appetite, vasodilatation, and decreased respiratory rate. Therefore, smoking weed is not recommended as a weight loss strategy, and it can have negative effects on overall health.