If the shape of the enzyme changes, the most likely result is that the enzyme will no longer function properly. This is because:

• Enzymes have a specific three-dimensional shape that fits their substrate like a key fits a lock.
• When the shape changes, the active site (where the substrate binds) may no longer match the substrate.
• This prevents the enzyme from binding to the substrate effectively.
• As a result, the enzyme cannot catalyze the chemical reaction efficiently or at all.
• This loss of function is often called denaturation and can be caused by changes in temperature, pH, or other environmental conditions.

In summary, a change in enzyme shape usually leads to a loss or reduction of enzyme activity.