Luke Perry died on March 4, 2019, at the age of 52, from a massive ischemic stroke. This type of stroke occurs when a blood clot blocks an artery leading to the brain. Despite being seemingly healthy and active, the stroke took his life quickly and unexpectedly. Factors such as his past smoking habits, genetic predisposition, and the stresses of frequent air travel may have contributed to this health event. Perry was hospitalized at his home in Sherman Oaks, California, and unfortunately never regained consciousness before passing away surrounded by family and friends.