Inhalants can lead to hypoxia primarily by displacing or reducing the amount of oxygen available to the brain and other tissues. When inhalants are inhaled, especially in enclosed or poorly ventilated spaces, they rapidly enter the lungs and bloodstream, but they also occupy space that would normally be filled by air. This reduces the effective concentration of oxygen that reaches the lungs and bloodstream, leading to decreased oxygen delivery to tissues. Prolonged or repeated inhalant use can sustain this oxygen deprivation, increasing the risk of brain injury and organ damage. In addition, some inhalants interfere with cellular respiration and mitochondrial function, further compromising the body's ability to utilize oxygen efficiently. Severe cases can result in loss of consciousness, arrhythmias, respiratory failure, or death, particularly with “sudden sniffing death” linked to certain aerosols or gases. Hypoxia from inhalant use is a medical emergency that requires immediate assessment and care.