The distance between Florence and Rome is approximately 261 kilometers (about 162 miles) by train or road. The road distance is slightly longer at around 273 kilometers (about 170 miles)

. Traveling by high-speed train is the fastest option, taking roughly 1 hour and 25 to 1 hour and 37 minutes to cover the distance between the two cities

. The train route is well-served, with frequent departures daily from Rome's Roma Termini station to Florence's Firenze Santa Maria Novella station

. In summary:

• Distance: ~261 km (162 miles) straight line and by train; ~273 km (170 miles) by road
• Fastest travel time by high-speed train: approximately 1 hour 25 minutes to 1 hour 37 minutes
• Other options include bus (around 3 hours 15 minutes) and driving (about 2 hours 40 minutes)