The driving distance from Miami to Key West is approximately 160 to 166 miles, depending on the exact starting point in Miami

. The drive typically takes about 3.5 to 4 hours without stops along the scenic Overseas Highway, which crosses numerous islands and bridges including the famous Seven Mile Bridge

. In summary:

• Distance: Around 160-166 miles
• Driving time: About 3.5 to 4 hours nonstop

This route is known for its beautiful ocean views and is considered one of the most picturesque road trips in Florida