The distance between Rome and Venice is approximately 512 kilometers (about 327 miles) by road, while the direct "as the crow flies" distance is around 394 kilometers (245 miles)

. Traveling by train, the route covers about 514 kilometers (around 320 miles), and the fastest high-speed trains take roughly 3 hours and 34 minutes to make the journey from Roma Termini to Venezia Santa Lucia station

. By car, the driving distance is about 525 kilometers and typically takes just under 5 hours depending on traffic and route

. In summary:

• Direct distance: ~394 km (245 miles)
• Road distance: ~512-525 km (327 miles)
• Train distance: ~514 km (320 miles)
• Fastest train time: ~3 hours 30-40 minutes
• Driving time: ~4 hours 50 minutes to 5 hours

The train is generally the fastest and most convenient option for traveling between Rome and Venice.