Fluconazole typically begins to work within 24 to 72 hours after administration. For mild infections like vaginal yeast infections, many people notice symptom relief, such as reduced itching and discharge, within 24 to 48 hours after a single 150 mg dose. However, complete resolution of the infection may take several days to up to one or two weeks depending on the severity and type of infection. More severe or systemic fungal infections may require longer treatment durations and higher doses, with symptom relief potentially taking days to weeks. Factors like the infection's severity, type, individual health status (e.g., immune system strength, kidney function), and adherence to prescribed dosage influence how fast fluconazole works. For best results, it is important to follow the healthcare provider’s instructions regarding dosage and duration. If symptoms do not improve within a few days or worsen, consulting a healthcare provider is advised.