Derrick Henry, known for his combination of size and speed, has reached a top speed of 21.29 mph in the NFL, which ranks as the eighth-fastest measured by the league's Next Gen Stats since 2018. He has surpassed 20 mph numerous times despite his large frame of around 250 pounds, which is exceptional for a player of his size. His notable speed was recorded during an 87-yard touchdown run against the Bills. Henry's speed allows him to compete as one of the fastest ball carriers in the league, second only to players like Tyreek Hill who have more frequent 20 mph runs.

Additionally, Henry is often recognized in gaming stats and player ratings with a speed rating of 93 and a 40-yard dash time around 4.54 seconds, further illustrating his quickness relative to his size.

In summary, Derrick Henry is extremely fast, being capable of hitting top speeds over 21 mph, which is remarkable given his powerful 250-pound build.