After taking Tylenol (acetaminophen), it is generally advisable to wait at least 24 hours before drinking alcohol for optimal safety because small amounts of Tylenol can stay in the body for up to 24 hours. This separation helps minimize the risk of liver damage, as both Tylenol and alcohol are processed by the liver and combining them can increase liver stress and toxicity. If drinking is moderate (up to one or two drinks), some sources say it may be relatively safe to consume alcohol after a normal dose of Tylenol, but heavier drinking or frequent use of Tylenol requires longer spacing or avoidance. In summary:

• Wait at least 24 hours after taking Tylenol before drinking alcohol for best safety.
• Drinking small amounts shortly after a dose may be less risky but is not generally recommended.
• Avoid combining if you drink heavily or take high doses of Tylenol.
• Consult with a healthcare provider for personalized advice, especially if you have liver issues.

This guidance is based on the drug's half-life of around 2 to 3 hours but recognizing that Tylenol metabolites can stay longer, and the liver's risk when combined with alcohol.