The duration of protection from rabies shots varies depending on whether the vaccination is for animals or humans, and the type of vaccine used.

For Animals (Dogs, Cats, etc.)

• The first rabies shot an animal receives is typically valid for 1 year.
• After the second-year booster, the rabies vaccine is generally valid for 3 years.
• Some states require annual vaccinations regardless of the vaccine's labeled duration.
• Scientific studies suggest immunity can last well beyond 3 years, with some evidence of protection up to 5 to 7 years or more, although official recommendations still usually limit boosters to every 1 to 3 years.
• Vaccination schedules and requirements are often governed by state laws and veterinary guidelines.
• If a vaccinated dog is exposed to rabies, immediate revaccination and observation for 45 days are required. Unvaccinated dogs exposed to rabies may face euthanasia or strict quarantine.

For Humans

• Rabies vaccine protection typically lasts at least 1 to 2 years, depending on the number of doses received.
• People at ongoing risk of rabies exposure may need booster doses to maintain protection.
• The vaccine does not provide lifelong immunity, and medical attention is necessary immediately after potential exposure, even if vaccinated.
• Post-exposure prophylaxis includes a series of rabies vaccine doses and sometimes human rabies immune globulin (HRIG), which provides immediate but short-term protection.

In summary, rabies shots for pets usually last 1 year after the initial dose and 3 years after boosters, with some evidence suggesting longer immunity. For humans, protection generally lasts 1 to 2 years, requiring boosters for continued risk