Air Force One typically takes about 6 to 7 hours to fly from the United States (e.g., Joint Base Andrews) to London, depending on exact routing and conditions. For example, a flight time listed from Maryland to UK airspace is approximately 7 hours 50 minutes to an RAF base used for refueling near London, followed by a short onward segment to the final London airport destination. This timing aligns with typical subsonic long-haul 747 speeds on transatlantic routes.