A suppository typically takes about 15 to 60 minutes to work, depending on its type and purpose. Laxative suppositories like glycerin usually work faster, often producing a bowel movement within 15 to 30 minutes. Medicated suppositories, such as those for pain relief or nausea, may take 15 to 60 minutes to dissolve and start working as the medication is absorbed into the bloodstream. The effectiveness of the suppository can also depend on factors like patient positioning (lying on the left side with knees bent), retention time after insertion (recommended 10 to 15 minutes), and whether the rectum is empty to help absorption.