Azithromycin typically begins working soon after the first dose, with peak concentrations in the body reached within about 2 to 3 hours after oral administration

. However, it may take a few days—usually around 2 to 3 days—before noticeable improvement in symptoms occurs

. The exact time for azithromycin to work depends on the type, cause, and severity of the infection. For example, some infections like genital chlamydia might clear within a week after a single dose, while others such as pneumonia may take longer to show symptom resolution despite consistent dosing over several days

. It is important to complete the full prescribed course of azithromycin even if symptoms improve earlier, to ensure the infection is fully treated and to prevent resistance

. In summary:

• Azithromycin reaches peak blood levels in about 2–3 hours after oral intake.
• Symptom improvement usually starts within 2–3 days.
• Full course completion is essential for effective treatment.
• Duration until feeling better varies by infection type and severity

Azithromycin remains in the body for an extended period due to its long half- life (about 68 hours), but clinical effects on symptoms are generally seen within a few days of starting treatment