Dupixent typically begins to work within 2 to 4 weeks for conditions like atopic dermatitis (eczema), with noticeable itch relief often starting in that timeframe. For clearer or mostly clear skin, it generally takes about 16 weeks. In asthma patients, some lung function improvements can start as early as 2 weeks, but significant benefits usually occur around 12 weeks. For other conditions treated by Dupixent, such as chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, and prurigo nodularis, initial improvements may be seen in a few weeks up to several months, depending on the condition. It's recommended to continue treatment for at least 16 weeks before evaluating effectiveness with a healthcare provider.