Ozempic typically starts to affect blood sugar levels within about 4 weeks, with the full effects usually seen after approximately 12 weeks. For weight loss, some people may notice appetite suppression in the first days to weeks, but noticeable weight loss often takes around 3 to 4 months, with best results over 6 months to a year. The medication dose is usually gradually increased over the first several weeks to minimize side effects and reach a maintenance level for optimal effect. Individual responses may vary based on factors such as dosage, metabolism, lifestyle, and health conditions.