Panadol, which contains paracetamol, usually takes around 30 minutes to 1 hour to start working for most people. The onset time can vary depending on factors like age, weight, and how severe the symptoms are. Some formulations of Panadol, such as Panadol Extra Advance with Optizorb, may start working faster, potentially in as little as 10 minutes due to faster absorption. Once it starts working, the effects typically last for about 4 to 6 hours. It is important to follow the recommended dosage instructions for safety and effectiveness.