Pantoprazole typically starts to work within 1 to 2 hours after taking the first dose by beginning to reduce stomach acid production. However, it may take several days—generally about 3 days—for its full effects to be noticeable for conditions like acid reflux (GERD). For more serious digestive conditions such as erosive esophagitis, it can take up to 8 weeks or longer to fully heal with pantoprazole treatment. Pantoprazole does not provide immediate relief and is not suitable for quick symptom relief like antacids do. The medication is usually taken once a day, and its effect on lowering stomach acid can last about 24 hours.