Paracetamol typically takes around 30 minutes to 1 hour to start working after taking it. The relief usually begins within 30 minutes for most people, but it can take up to an hour depending on factors like age, weight, and how the medication is taken. Once it takes effect, paracetamol keeps working for about 5 hours. It can be taken with or without food, but taking it on an empty stomach may help it work faster. It’s important to follow dosage instructions and wait at least 4 hours between doses to avoid overdose risks.