Trazodone can start working within 30 minutes to 2 hours for sleep-related issues, producing sedative effects quickly. However, for conditions like depression and anxiety, it typically takes longer—about 1 to 2 weeks to start working and 4 to 6 weeks (sometimes up to 6 to 8 weeks) to feel the full therapeutic benefit. The exact timing varies based on the condition being treated, the dosage, and individual response to the medication.