A yeast infection pill like fluconazole typically starts to work within 24 to 48 hours, with symptoms such as itching and irritation often improving within the first day. More noticeable improvements, like a reduction in discharge and swelling, usually occur within three days, and it can take up to a week for the infection to fully clear. For mild infections, a single 150 mg dose is often enough, but more severe or recurring infections may require additional doses or longer treatment. If symptoms do not improve after a few days or worsen, it is important to follow up with a healthcare provider, as longer or repeated treatments might be necessary. The medication continues to work in the body as it is being cleared, so symptom relief precedes complete eradication of the infection.