Wegovy (semaglutide) typically begins to show weight loss effects within the first month of treatment, with many patients losing about 2% of their starting body weight after 4 weeks

. Weight loss tends to be gradual and steady over time, with average reductions of approximately:

• 4% body weight after 2 months
• 6% after 3 months
• 8% after 4 months
• 10% by 20 weeks (about 5 months)
• 15% after 12 months (1 year)
• Around 15-17% after 15 to 17 months (68 weeks)

The medication dosage is usually increased slowly over about 17 weeks to the full maintenance dose of 2.4 mg weekly, which helps reduce side effects and optimize weight loss

. Maximum weight loss is generally seen after 12 to 15 months of consistent use combined with lifestyle changes such as a reduced-calorie diet and increased physical activity

. In summary, noticeable weight loss can start within the first month, but significant and sustained weight loss typically takes several months to over a year on Wegovy, with best results achieved alongside healthy diet and exercise habits.