Vyvanse (lisdexamfetamine) is a long-acting stimulant medication primarily used to treat ADHD and binge eating disorder. The effects of Vyvanse typically last about 14 hours after taking a dose

. Key details about Vyvanse duration and metabolism:

• Onset and Peak: Vyvanse starts working within 1.5 to 2 hours, with peak levels reached around 3.5 to 4.5 hours after ingestion

• Duration of Effect: The therapeutic effects generally persist for up to 14 hours, making it suitable for once-daily morning dosing

• Half-Life: The active metabolite, dextroamphetamine, has a half-life of approximately 12 hours. This means it takes about 12 hours for the body to eliminate half of the drug

• Elimination Time: It usually takes about 2.5 days (around five half-lives) for Vyvanse to be mostly cleared from the system

• Variability: Factors such as age, weight, metabolism, kidney function, and other medications can influence how long Vyvanse lasts and stays detectable in the body

In summary, Vyvanse's effects last about 14 hours, with the drug remaining in the body for up to 2.5 days after the last dose. This long duration supports its once-daily dosing schedule in the morning to avoid interference with sleep