Vyvanse (lisdexamfetamine) typically stays in your system for about 2.5 to 3 days (around 60 hours) after the last dose. This estimate is based on the half-life of its active metabolite, dextroamphetamine, which is approximately 12 hours. It generally takes about five half-lives for a drug to be eliminated from the body, so most of Vyvanse is cleared within this timeframe

. Key points about Vyvanse elimination:

• The parent drug lisdexamfetamine has a very short half-life (less than 1 hour) and is usually undetectable after about 8 hours

• Vyvanse is converted in the body to dextroamphetamine, which has the longer half-life (~12 hours) responsible for the drug's effects and detection window

• Vyvanse can be detected in urine for up to 3 to 5 days after the last dose, in blood for about 8 to 12 hours, in saliva for up to 2 days, and in hair for up to 90 days

• Factors affecting how long Vyvanse stays in your system include dosage, frequency of use, metabolism, age, weight, kidney and liver function, hydration, and interactions with other substances

In summary, Vyvanse is typically eliminated from the body within 2 to 3 days, but detection windows vary depending on the type of drug test and individual factors.